Mixed Maintenance Genes
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
All 16 genes show weak module membership and uniform expression across subsets with unknown coherence. The gene set is functionally heterogeneous, spanning cytoskeletal organization (LIMA1, FMN1, PLEKHG2), intracellular signaling (PDE4A, SPRY1, TMEM88), metabolic maintenance (OGDH, GMPR), vesicular/lysosomal function (ATP6V1A, KIF1B), and lipid homeostasis (ABCA1). No single coherent biological program dominates. The uniform expression and weak co-regulation suggest this is a low-confidence catch-all module of broadly expressed maintenance genes rather than a specific biological program.
Genes
Most correlated modules
- Intracellular Kinase Signaling · correlation 0.74
- Kinase Phosphatase Signaling · correlation 0.74
- Autophagy & Proteostasis · correlation 0.69
- NF-κB Immune Signaling · correlation 0.69
- Mixed Signaling Regulation · correlation 0.66
- pDC Activation Response · correlation 0.62
- DNA Damage Response · correlation 0.62
- Chemokine Migration Response · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.