RNA Splicing Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 15 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes and the majority of the module are RNA-binding proteins and pre-mRNA splicing regulators: RBM25, RBM39, RBM5, TRA2B, FUS, DDX5, SFPQ, SF3B1, PRPF38B, RSRC2, CCNL1 (cyclin L1, splicing-coupled), CDK12 (splicing kinase), GPATCH2L (G-patch splicing factor). All genes show weak membership and uniform expression, indicating a poorly-resolved but thematically coherent splicing/RNA-processing housekeeping cluster rather than a regulated biological program.
Genes
Most correlated modules
- JAK-STAT Signaling · correlation 0.88
- Transcription Regulation · correlation 0.84
- Transcriptional Regulation · correlation 0.82
- Mixed Housekeeping · correlation 0.81
- Chromatin Remodeling · correlation 0.81
- pDC Identity & Splicing · correlation 0.81
- RNA Processing · correlation 0.79
- Chromatin Remodeling · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.