DNA Repair & Chromatin
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 22 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub genes include TRIM8 (E3 ubiquitin ligase, immune regulation), APPL1 (endosome signaling adaptor), BCL7A (SWI/SNF chromatin remodeling), SMC3 (cohesin complex, chromosome segregation), NUCKS1 (chromatin remodeling/DNA repair), PRKDC (DNA-PKcs, DNA double-strand break repair), RECQL (RecQ helicase, DNA repair), EHMT2 (G9a, histone methyltransferase), BRD7 (SWI/SNF, chromatin), DYNC1I2 (dynein, cytoskeletal transport), MOB1A (Hippo pathway), SRSF5 (splicing). The strongest theme is DNA repair and chromatin remodeling (PRKDC, RECQL, NUCKS1, SMC3, EHMT2, BRD7, BCL7A), consistent with a housekeeping DNA maintenance program. The neighbor context of similarly weak modules supports a loosely co-expressed housekeeping interpretation.
Genes
Most correlated modules
- Endosomal Trafficking · correlation 0.92
- Cell Cycle Regulation · correlation 0.91
- ER Quality Control · correlation 0.90
- Transcriptional Regulation · correlation 0.90
- RNA Processing · correlation 0.89
- Ubiquitin-Proteasome Regulation · correlation 0.87
- IFN Receptor Signaling · correlation 0.86
- ER Protein Folding · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.