Transcriptional Coactivation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 10 of 35 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub genes include EP300 (histone acetyltransferase/transcriptional coactivator), DDX17 (RNA helicase/splicing), ARFGAP3 (COPI vesicle trafficking), TUT4/TUT7 (terminal uridylyl transferases, RNA decay/miRNA regulation), SON (splicing factor), OGA (O-GlcNAcase), SF3A1 (spliceosome), MCM3AP (DNA replication/acetyltransferase), YY1 (transcription factor), UBE2G2 (E3 ubiquitin conjugating enzyme), XBP1 (UPR/ER stress transcription factor), COPB1 (COPI vesicle coat), HSPA13 (ER chaperone), BRD1 (bromodomain/chromatin). The strongest threads are RNA processing/splicing (DDX17, SON, SF3A1, TUT4, TUT7, TNRC6B) and transcriptional regulation (EP300, YY1, BRD1). XBP1, HSPA13 suggest UPR. ARFGAP3/COPB1 suggest vesicular trafficking. This is a mixed housekeeping module; RNA processing is the most represented sub-theme.
Genes
Most correlated modules
- IFN Receptor Signaling · correlation 0.83
- Epigenetic Silencing · correlation 0.82
- ER Quality Control · correlation 0.81
- DNA Repair & Chromatin · correlation 0.79
- Ubiquitin-Proteasome Regulation · correlation 0.79
- Genome Organization · correlation 0.73
- RNA Processing Regulation · correlation 0.73
- RNA Processing · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.