Lipid Transport & Membrane
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes include SPTLC2 (serine palmitoyltransferase, sphingolipid biosynthesis), OSBPL8 (oxysterol-binding protein, lipid transfer), VPS13C (lipid transport at membrane contact sites), BLTP3B (bridge-like lipid transfer), CLCN3 (chloride channel, endosomal), TMOD3 (tropomodulin, actin filament capping), ANTXR2 (cell adhesion/matrix), PECAM1 (CD31, adhesion/migration). The module combines lipid metabolism/transport with membrane and cytoskeletal elements. All genes are weakly co-regulated and uniformly expressed. The lipid transfer theme (VPS13C, OSBPL8, BLTP3B, SPTLC2) is the strongest thread, possibly reflecting membrane homeostasis.
Genes
Most correlated modules
- Centrosome Organization · correlation 0.87
- ER Quality Control · correlation 0.84
- DNA Repair Housekeeping · correlation 0.84
- pDC Identity Signaling · correlation 0.83
- Mixed Regulatory Background · correlation 0.83
- Transcriptional Regulation · correlation 0.83
- Chromatin Remodeling · correlation 0.82
- Ubiquitin-Proteasome Regulation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.