Mixed Regulatory Background
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 4 of 14 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Hub genes include: TMEM245 (transmembrane), AGO1 (Argonaute/miRNA-mediated silencing), CCDC6 (coiled-coil, involved in DNA damage response/fusion oncogene), FNBP1L (actin/endocytosis), SHOC2 (RAS-MAPK scaffold), PPP1R3E (PP1 regulatory subunit), CPLANE1 (ciliogenesis), SNAPC3 (snRNA-activating protein complex), PAPOLG (poly(A) polymerase), ACIN1 (apoptosis/RNA processing), ZNF genes (transcription factors). AGO1 and PAPOLG suggest RNA processing, CPLANE1 and RPGR suggest cilia-related biology, but overall the module is highly heterogeneous with no dominant program. This is a weakly defined background module, consistent with neighbors M41 and M31.
Genes
Most correlated modules
- Mixed Regulatory Background · correlation 0.89
- DNA Damage Response · correlation 0.87
- Low-coherence Background · correlation 0.85
- Mixed Regulatory Background · correlation 0.84
- Autophagy & Proteostasis · correlation 0.83
- Stress Kinase Signaling · correlation 0.82
- Lipid Transport & Membrane · correlation 0.78
- Mixed Regulatory Background · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.