RNA Processing Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 8 of 28 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub genes include TAOK1 (MAP3K kinase, stress signaling), SUPT5H (transcription elongation, SPT5), ITSN2 (endocytosis/intersectin), UBR5 (E3 ubiquitin ligase), NONO (nuclear RNA binding/paraspeckles), UGGT1 (ER glycoprotein quality control), SNRNP200 (spliceosome helicase), UBA6 (ubiquitin/UBL activating enzyme), BDP1 (RNA Pol III), IKBKB (IKK-beta, NF-kB signaling), NPAT (histone gene transcription/cell cycle), CHD4 (chromatin remodeling/NuRD), CEP350 (centrosome). This is a highly mixed module spanning RNA processing, ubiquitin, chromatin, and signaling. No single program dominates; the best unifying theme across the top genes is large-scale RNA/transcriptional regulation and ubiquitin-mediated proteostasis — classic housekeeping functions.
Genes
Most correlated modules
- Chromatin Remodeling · correlation 0.88
- Genome Organization · correlation 0.88
- Mixed Regulatory Background · correlation 0.82
- Chromatin & Ubiquitin · correlation 0.80
- JAK-STAT Signaling · correlation 0.80
- ER Quality Control · correlation 0.79
- Centrosome Organization · correlation 0.79
- Ubiquitin-Proteasome Regulation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.