Mixed Housekeeping
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 28 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Gene composition is highly mixed: POLE2 (DNA polymerase epsilon subunit, DNA replication/repair), DYNC2H1 (cytoplasmic dynein 2, intraflagellar transport/cilia), EVC2 (hedgehog signaling at cilia), SLC35D1 (Golgi UDP-glucuronate transporter), AGPAT4 (lysophospholipid acyltransferase), STARD13 (RhoGAP), RGS12 (RGS domain signaling), MLYCD (malonyl-CoA decarboxylase, fatty acid metabolism), SYTL2 (synaptotagmin-like, vesicle). No coherent program; the cilia-related genes (DYNC2H1, EVC2) are notable but insufficient to define the module given the weak membership of all genes.
Genes
Most correlated modules
- Mixed Housekeeping · correlation 0.91
- Chromatin Regulation · correlation 0.90
- Mixed Housekeeping · correlation 0.87
- Epigenetic Regulation · correlation 0.83
- CX3CR1 Migration · correlation 0.82
- TLR Signaling Regulation · correlation 0.80
- Cilia & Centrosome · correlation 0.75
- Chromatin RNA Regulation · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.