RNA Processing
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 25 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub genes include NCL (nucleolin, rRNA processing/ribosome biogenesis), SERBP1 (RNA-binding, translation regulation), HNRNPD/HNRNPK/HNRNPA3/HNRNPA2B1/HNRNPR (heterogeneous nuclear ribonucleoproteins, RNA processing/splicing), XRN2 (5'-3' exoribonuclease, RNA degradation), EIF2AK1/EIF4G2 (translation initiation), TAF7 (TFIID transcription), CANX (calnexin, ER chaperone), XRCC5 (Ku80, DNA repair), PA2G4 (ErbB3-binding, ribosome assembly). The dominant theme is RNA processing and post-transcriptional regulation, particularly the HNRNP family. This is a housekeeping RNA metabolism module. Neighbor context supports a general housekeeping interpretation.
Genes
Most correlated modules
- DNA Repair & Chromatin · correlation 0.89
- ER Quality Control · correlation 0.86
- Cell Cycle Regulation · correlation 0.85
- Endosomal Trafficking · correlation 0.84
- ER Protein Folding · correlation 0.82
- Genome Organization · correlation 0.80
- Ubiquitin-Proteasome Regulation · correlation 0.75
- Histone Expression · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.