Mitotic Cell Cycle
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 29 genes have a known function matching the annotation |
Why this annotation
Despite weak coherence and uniform expression across all subsets, the top hub genes include clear cell cycle regulators: WEE1 (G2/M checkpoint kinase), NCAPG (condensin complex, chromosome condensation during mitosis), GAS2L3 (cytokinesis regulator), and histone genes H2AC11 and H4C6 (replication-coupled histone synthesis). SAP30 participates in transcriptional repression linked to cell cycle control. The remaining genes (PAX8, TCF7L2, LCN8, ADORA3, etc.) are diverse and weakly associated, indicating a mixed or noisy module. The dominant biological signal, though weak, points to a cell cycle/mitotic program.
Genes
Most correlated modules
- Mixed Signaling · correlation 0.86
- Survival & Adhesion · correlation 0.78
- Hematopoietic Development · correlation 0.77
- Cell Cycle Regulation · correlation 0.69
- Mixed Signaling Regulation · correlation 0.59
- Antiviral Innate Sensing · correlation 0.59
- Myeloid Differentiation · correlation 0.45
- Progenitor Transcription · correlation 0.37
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.