Epigenetic Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 4 of 18 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub genes include LRRC8A (volume-regulated anion channel), ADNP2 (chromatin remodeling), DOT1L (H3K79 methyltransferase), EZH2 (PRC2 H3K27 methyltransferase), and CARM1 (H3R17 methyltransferase). The presence of multiple histone-modifying enzymes (DOT1L, EZH2, CARM1) alongside JAK3 and UPF1 suggests a loose epigenetic/chromatin regulation theme. Despite weak coherence, the epigenetic regulators are the most coherent sub-theme among hub genes.
Genes
Most correlated modules
- IFN-Vesicular Response · correlation 0.79
- Cell Cycle Regulation · correlation 0.79
- Cell Cycle Regulation · correlation 0.71
- Transcription Regulation · correlation 0.71
- Chromatin Remodeling · correlation 0.70
- Rho GEF Migration · correlation 0.70
- Metabolic Stress Response · correlation 0.69
- Glucocorticoid Stress Response · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.