pDC Identity
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
CLEC4C (BDCA-2/CD303, the canonical pDC surface marker), IRF8 (master transcription factor for pDC lineage commitment), PLAC8 (expressed in pDCs and monocytes), SELL (CD62L, lymph node homing receptor expressed on circulating pDCs), CD52 (highly expressed on pDCs), DNASE1L3 (DNase expressed in pDCs/DCs), CYBB (NOX2, expressed in pDCs for ROS and TLR signaling), GAPT (GRB2-binding adaptor, pDC signaling), CCDC50 (involved in innate immune signaling). This module captures core pDC identity and lineage-defining genes. Neighbor M7 also has pDC markers (LILRA4, PLD4, SPIB), confirming this neighborhood reflects pDC identity programs.
Genes
Most correlated modules
- Monocyte Chemotaxis · correlation 0.88
- ER Protein Folding · correlation 0.85
- Lysosomal Ag Processing · correlation 0.83
- ER Protein Folding · correlation 0.82
- Fc Receptor Trafficking · correlation 0.81
- Transcriptional Regulation · correlation 0.81
- Type I Interferon · correlation 0.80
- Immune Cell Migration · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.