Hematopoietic Development
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include SOCS2 (suppressor of cytokine signaling), LMO2 and MEIS1 (hematopoietic transcription factors), CDCA7 (c-Myc target, cell cycle/lymphocyte proliferation), LAT2 (linker for B cell/mast cell activation), MATK (lymphocyte-specific kinase), and PRKD2 (PKD2, immune cell signaling). The combination of hematopoietic TFs (LMO2, MEIS1) with cytokine regulation (SOCS2) and lymphoid signaling (LAT2, MATK) suggests a hematopoietic progenitor or early DC differentiation program. All genes are weakly defined, limiting confidence.
Genes
Most correlated modules
- Survival & Adhesion · correlation 0.88
- Progenitor Transcription · correlation 0.84
- Mixed Signaling · correlation 0.82
- Mitotic Cell Cycle · correlation 0.77
- Glycolytic Metabolism · correlation 0.66
- Mixed Signaling Regulation · correlation 0.65
- Post-transcriptional Regulation · correlation 0.64
- Myeloid Differentiation · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.