Fc Receptor Trafficking
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include FCER1G (Fc receptor gamma chain for signaling), FCGRT (neonatal Fc receptor involved in IgG recycling), VAMP8 (vesicular SNARE for endosomal/lysosomal fusion), SVIP (VCP-interacting protein regulating ER/vesicle trafficking), CST3 (cystatin C, lysosomal cysteine protease inhibitor), and ARHGAP9 (Rho GTPase regulator). The module combines Fc receptor biology with vesicular and endosomal trafficking machinery, consistent with pDC endocytic/phagocytic receptor recycling programs. All genes show weak membership and uniform expression, indicating a loosely co-regulated housekeeping-adjacent vesicular program.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.93
- ER Redox Homeostasis · correlation 0.90
- Clathrin-mediated Endocytosis · correlation 0.90
- Lysosomal mTOR Signaling · correlation 0.88
- ER Protein Folding · correlation 0.88
- Actin Cytoskeletal Remodeling · correlation 0.87
- Mitochondrial Assembly · correlation 0.86
- Lysosomal Ag Processing · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.