ER Protein Folding
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 21 genes have a known function matching the annotation |
Why this annotation
The module is dominated by ER protein translocation and folding machinery: SSR4 and SSR3 (signal sequence receptor/translocon-associated protein complex), SEC11C (signal peptidase complex), SEC61G and SEC61B (translocon pore subunits), SERP1 (stress-associated ER protein, stabilizes translocon), PPIB (cyclophilin B, ER peptidyl-prolyl isomerase), PDIA3 and PDIA6 (protein disulfide isomerases), NUCB2 (ER calcium-binding), MZB1 (marginal zone B and B1 cell-specific protein, ER chaperone expressed in pDCs and plasma cells). This is a coherent ER protein processing/secretory pathway module. Neighbor M108 also has ER components (TMX1, BCAP31), supporting shared ER biology across the neighborhood.
Genes
Most correlated modules
- ER Redox Homeostasis · correlation 0.94
- Fc Receptor Trafficking · correlation 0.88
- Actin Cytoskeletal Remodeling · correlation 0.86
- ER-Golgi Trafficking · correlation 0.86
- Metabolic Housekeeping · correlation 0.86
- Clathrin-mediated Endocytosis · correlation 0.86
- Lysosomal mTOR Signaling · correlation 0.83
- Type I Interferon · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.