ER Stress UPR
Gene co-expression module in Plasma cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
Key hub genes include MBTPS1 (site-1 protease, cleaves ATF6 and SREBP in the UPR and sterol sensing pathways), TXNDC5 (ER-resident thioredoxin domain protein upregulated in ER stress), and RRBP1 (ribosome-binding protein 1, ER membrane). CPEB4 regulates cytoplasmic polyadenylation of mRNAs encoding UPR components. TP53INP1 is a stress-induced p53 target. PLCG2 (phospholipase C gamma 2) is a B-cell receptor signaling effector. RBM6 (RNA binding), SYNE2 (nuclear envelope/LINC complex), EHMT1 (histone methyltransferase), PIEZO1 (mechanosensitive ion channel), and SEC14L1 (lipid transfer) add diverse context. The module is significantly upregulated in inflammation and shows uniform expression across subsets, suggesting a broadly active stress program. The ER stress/UPR signal (MBTPS1, TXNDC5, RRBP1, CPEB4) is the most coherent biological theme, consistent with high secretory load in activated plasmablasts during inflammation.
Genes
Most correlated modules
- Innate Immune ISG · correlation 0.87
- Plasmablast Differentiation · correlation 0.85
- DNA Damage Response · correlation 0.84
- Plasmablast Proliferation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.