Plasmablast Differentiation
Gene co-expression module in Plasma cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 20 genes have a known function matching the annotation |
Why this annotation
TCF4 (E2-2/TCF7L2 isoform; the master transcription factor for plasmablast/plasma cell differentiation) is a strong hub gene. SON (nuclear speckle scaffold, splicing regulation), ZRANB2 (splicing factor), MBNL1 (RNA binding, splicing), PNISR (splicing), SUPT6H (transcription elongation factor) support active transcriptional/splicing programs. NSD1 (histone H3K36 methyltransferase), SP3 (transcription factor), BDP1 (RNA Pol III TF), HP1BP3 (chromatin compaction), CBX6 (PRC1 component) add chromatin/transcriptional regulation. SEC31A and SCFD1 (COPII vesicle components) link to secretory pathway. TAPBP (tapasin) suggests antigen presentation context. This module captures the transcriptional differentiation program of plasmablasts driven by TCF4.
Genes
Most correlated modules
- Plasmablast Proliferation · correlation 0.94
- DNA Damage Response · correlation 0.93
- Innate Immune ISG · correlation 0.92
- ER Secretory Expansion · correlation 0.92
- Plasma Cell Differentiation · correlation 0.86
- ER Stress UPR · correlation 0.85
- ER-Golgi Secretory Pathway · correlation 0.85
- Unfolded Protein Response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.