DNA Damage Response
Gene co-expression module in Plasma cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Multiple hub genes are directly involved in the DNA damage response (DDR): RNF168 (E3 ubiquitin ligase that monoubiquitinates H2A at DSBs, central DDR mediator), CDK12 (kinase regulating DDR gene transcription), PPP4R3A (phosphatase regulating RPA and DDR), ANKLE2 (nuclear envelope protein involved in DNA damage signaling), UBR5 (E3 ligase with DDR roles). ACIN1 links apoptosis to DNA damage. PRPF4B (splicing kinase), NOL8 (nucleolar), ZC3H18, NSUN6 (RNA methyltransferase), and GTF2F1 (transcription) add transcriptional/RNA processing context. The module is significantly upregulated in inflammation (both UC and CD), consistent with replication stress or genotoxic stress in proliferating plasmablasts during active disease. Neighbor M39 shares plasmablast enrichment and mild inflammation association, but M65 is more specifically DDR-focused.
Genes
Most correlated modules
- Plasmablast Proliferation · correlation 0.95
- Plasmablast Differentiation · correlation 0.93
- Innate Immune ISG · correlation 0.90
- Plasma Cell Differentiation · correlation 0.85
- ER Stress UPR · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.