Plasmablast Proliferation
Gene co-expression module in Plasma cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Weak coherence module enriched in plasmablasts. Hub genes include spliceosome components (LUC7L3, SNRNP200, SNRNP70, SUGP2, ARGLU1, PABPN1), RNA binding proteins (RBM26, LARP4), and notably centrosome/centriole genes (CEP152, CEP295, CENPJ with 6-8x plasmablast enrichment) and FIGNL1 (DNA repair/replication). The centrosome genes are highly plasmablast-enriched, suggesting proliferating plasmablasts. DYNC1H1 (dynein) and PDS5B (cohesin) further support a cell division/mitotic context. The spliceosome genes may co-vary due to shared transcriptional burst in proliferating cells. Overall this reflects a mixed module with a centrosome/cell division sub-program in proliferating plasmablasts.
Genes
Most correlated modules
- DNA Damage Response · correlation 0.95
- Plasmablast Differentiation · correlation 0.94
- Innate Immune ISG · correlation 0.90
- ER Secretory Expansion · correlation 0.90
- COPI Vesicle Trafficking · correlation 0.89
- ER Stress UPR · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.