Innate Immune ISG
Gene co-expression module in Plasma cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include SAMD9L and RNF213, both well-characterized interferon-stimulated genes (ISGs) with antiviral and innate immune functions. ITPR2 (calcium signaling), LAX1 (lymphocyte signaling adaptor), and FUT8 (fucosyltransferase involved in IgG glycosylation) add immune regulatory context. SMCHD1 has roles in innate immune gene regulation. The module is moderately coherent with plasmablast enrichment. The mild inflammation association (n.s.) and mixed membership scores suggest a partially activated innate immune/ISG program in plasmablasts rather than a canonical interferon response. Neighbor M65 shows stronger DNA damage/repair signals, supporting that M39 captures a distinct but related stress-immune program.
Genes
Most correlated modules
- Plasmablast Differentiation · correlation 0.92
- Plasmablast Proliferation · correlation 0.90
- DNA Damage Response · correlation 0.90
- ER Stress UPR · correlation 0.87
- Plasma Cell Differentiation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.