Progenitor S-phase
Gene co-expression module in Tuft cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes TYMS (thymidylate synthase, S-phase), UBE2C (ubiquitin-conjugating enzyme active in mitosis/APC-C), GGH (folate/nucleotide metabolism), EXOSC5 (RNA exosome subunit), and NXPE4/TRABD2A (pre-tuft identity) define a pre-tuft progenitor proliferation program. All genes are strongly enriched in pre_tuft subset. TYMS and UBE2C are canonical S/G2-M markers. The module is tightly co-regulated (core coherence) and represents active DNA synthesis in tuft precursors.
Genes
Most correlated modules
- Secretory Progenitor Commitment · correlation 1.00
- Prostaglandin Biosynthesis · correlation 0.99
- Metallothionein Stress Response · correlation 0.99
- G2/M Progenitor Proliferation · correlation 0.99
- Precursor Cell Cycle · correlation 0.98
- Pre-tuft WNT Secretion · correlation 0.98
- Epithelial Progenitor Differentiation · correlation 0.98
- Mitochondrial Biogenesis · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.