G2/M Progenitor Proliferation
Gene co-expression module in Tuft cells
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
TOP2A (topoisomerase II alpha, G2/M marker), CENPF (centromere protein F, mitosis), CDCA7 (cell division cycle associated 7, S-phase/DNA methylation), NUPR1 (nuclear protein 1, stress/p53 pathway), MT1G (metallothionein 1G), PTGDR (prostaglandin D2 receptor — relevant to tuft cell identity), PTPRO (receptor tyrosine phosphatase), NXPE1 (pre-tuft marker), SHD (Src homology domain), CKAP4 (cytoskeleton-associated protein). TOP2A, CENPF, and CDCA7 are canonical G2/M cell cycle genes. NUPR1 and MT1G suggest co-occurring stress. This module represents a G2/M proliferative state in pre-tuft progenitors, with PTGDR hinting at tuft lineage priming.
Genes
Most correlated modules
- Proliferating Mucus Secretory · correlation 0.99
- Progenitor S-phase · correlation 0.99
- Secretory Progenitor Commitment · correlation 0.98
- Pre-tuft WNT Secretion · correlation 0.98
- Epithelial Progenitor Differentiation · correlation 0.97
- Metallothionein Stress Response · correlation 0.97
- Precursor Cell Cycle · correlation 0.97
- Progenitor Metabolic Reprogramming · correlation 0.97
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.