A1CF — APOBEC1 complementation factor
A1CF belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
A1CF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Cytoskeletal Remodeling Cytoskeletal | ANK3, BMP3, CCNYL1, DISP2, DOCK4, ECE1, ENPP1, FGFR3 +18 more | View in SCUBA |
About the gene
| Synonyms | ACF, ACF64, ACF65, APOBEC1CF, ASP |
|---|---|
| Chromosome | 10: 50799409-50885675 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | mRNA processing |
Function
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense- mediated decay.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.