Cytoskeletal Remodeling
Gene co-expression module in Colonocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 27 genes have a known function matching the annotation |
Why this annotation
SCIN (scinderin, actin-severing), ANK3 (ankyrin-3, membrane-cytoskeleton scaffold), DOCK4 (Rac GEF, cytoskeletal remodeling), PLXNA2 (plexin A2, cell guidance/migration), UNC5B (netrin receptor, axon/cell guidance), A1CF (RNA editing), MALT1 (NF-κB signaling), BMP3 (TGF-beta family morphogen), ENPP1 (ectonucleotidase), PRR5L (mTORC2), and SLC3A1 (amino acid transporter) are present. Mixed BEST4/sen_colono enrichment. The module is heterogeneous but the top hub genes (SCIN, ANK3, DOCK4, PLXNA2, UNC5B) converge on cytoskeletal remodeling and cell guidance, likely in a BEST4/mature colonocyte context. Coherence is strong but biological program is mixed.
Genes
Most correlated modules
- BEST4 Colonocyte Identity · correlation 0.85
- Brush Border Cytoskeleton · correlation 0.73
- Lipid Xenobiotic Metabolism · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.