ANK3 — Ankyrin 3
ANK3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANK3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell Maturation B cell maturation | ANTXR2, CD24, COL4A3, COL4A4, CSGALNACT1, ITM2C, PDCD4, PPP1R2C +3 more | View in SCUBA |
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | ACVR1C, ADA2, CAMK4, CHD7, GCLM, GNAO1, MPP7, NME4 +15 more | View in SCUBA |
| Enterocytes | Apicobasal polarity Migration & adhesion | BRINP3, CHPT1, FOXP1, MCTP2, NEO1, PARD3B, VAV3 | View in SCUBA |
| Fibroblasts | CCL11 Secretory Fibroblast ECM production | ARHGAP24, CCL11, COL16A1, COL18A1, DTX4, F11R, GABRA2, KAZN +5 more | View in SCUBA |
| Gamma-delta T cells | T Cell Development T cell maturation | ATF7IP2, CERK, ERN1, FKBP11, LRIG1, MICAL2, PAG1, PBXIP1 +4 more | |
| Glial cells | Neural Migration Scaffold Cytoskeletal | ABLIM1, ALCAM, CAB39L, GAS2L3, GFRA3, IQGAP2, NRXN1, RELN +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ARHGAP15, ARL15, BCAS3, CAMKMT, CCDC91, DPYD, EDA, IMMP2L +13 more |
About the gene
| Chromosome | 10: 60026298-60733490 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
Function
Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption. Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.