BMP3 — Bone morphogenetic protein 3
BMP3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BMP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Surface colonocyte differentiation Epithelial development | AGR3, ATP1B1, CLDN3, DSP, KLF5, KRT20, NEURL1B, PDLIM1 +2 more | View in SCUBA |
| Fibroblasts | BMP Developmental Identity Developmental | ALCAM, EN1, KANK4, LRRC38, LRRTM1, LY6H, PRSS2, SLC35F3 +3 more | View in SCUBA |
About the gene
| Chromosome | 4: 81030708-81057627 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Molecular function | Cytokine, Developmental protein, Growth factor |
| Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Function
Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.