DOCK4 — Dedicator of cytokinesis 4
DOCK4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DOCK4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous Endothelial Identity Endothelial cell development | ABI3, CCDC85B, EHD4, EVA1B, EXOC3L2, HDAC7, ITGA6, MCF2L +8 more | View in SCUBA |
| Enterocytes | Surface colonocyte transport Absorption | CA4, CD46, CITED1, CLCN1, GSN, HSPB1, ITM2C, LYPD8 +4 more | View in SCUBA |
| Lymphatic endothelial | Hippo-Adhesion Signaling migration & adhesion | ANKRD17, FER, GPHN, PRKCE, PTPRM, STAG1, STK3, UBE2E2 +1 more | View in SCUBA |
| Macrophages | Rho GTPase Signaling Cytoskeletal | ABCC1, ABR, ANKRD17, ARFGEF2, ARHGAP10, ARID2, ATAD2B, ATP9B +44 more | View in SCUBA |
| Monocytes | SPP1+ Inflammatory Macrophage Inflammatory | DUSP4, FLT1, GPR137B, IL7R, INHBA, MMP14, NECTIN2, SDC2 +6 more | View in SCUBA |
| Neutrophils | NF-κB Signaling Inflammatory | ATP13A3, BMP6, DSE, FLT1, HIVEP2, IRAK2, KIFC3, MAML2 +2 more |
About the gene
| Synonyms | FLJ34238, KIAA0716 |
|---|---|
| Chromosome | 7: 111726110-112206407 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. Involved in regulation of adherens junction between cells. Plays a role in cell migration. Has a higher guanine nucleotide exchange factor activity compared to other isoforms
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.