ABO — ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
ABO belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABO's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene nuclear transcripts Technical artifact | AIG1, ATRN, CACNB2, FOXN3, IMMP2L, KCNJ3, PLA2R1, TIAM2 | View in SCUBA |
About the gene
| Synonyms | A3GALNT, A3GALT1 |
|---|---|
| Chromosome | 9: 133233278-133276024 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
Function
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. Glycosyltransferase that catalyzes the transfer of carbohydrates to H antigen, forming the antigenic structures of the ABO blood group
Human Protein Atlas · Open Targets
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.