FOXN3 — Forkhead box N3

FOXN3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

FOXN3's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	IL10/cytokine signaling Immune regulation	CASK, CCDC141, IL10RA, IL7, SLC12A6, STAMBPL1, TMEM154, TNFRSF13B +4 more	View in SCUBA
Enterocytes	Long-gene nuclear transcripts Technical artifact	ABO, AIG1, ATRN, CACNB2, IMMP2L, KCNJ3, PLA2R1, TIAM2	View in SCUBA
Gamma-delta T cells	JNK/MAPK Stress Signaling Stress	ABTB3, BICRAL, COP1, DICER1, ELMO1, ERC1, FBXO11, FCHSD2 +19 more
Goblet cells	Colonocyte Differentiation Program Epithelial development	ASCL2, CAMK1D, CDK6, EDIL3, ENTPD5, HMGCS2, IRF2BP2, KLF5 +8 more	View in SCUBA
Innate lymphoid cells	ILC3 identity Differentiation	ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG +31 more	View in SCUBA
Macrophages	Chromatin Epigenetic Regulation Housekeeping	ABHD17B, ANKH, ARHGAP21, CCNH, CTTNBP2NL, DMXL1, EEIG2, ELF2 +21 more	View in SCUBA
Mucosal-associated invariant T cell	Calcium Signal Integration TCR Signaling	ANKRD44, ARB2A, CAMK2D, DOCK10, ELMO1, EXOC4, FCHSD2, FNDC3A +20 more

About the gene

Synonyms	C14orf116, CHES1
Chromosome	14: 89124871-89619149
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding, Repressor
Biological process	Cell cycle, Transcription, Transcription regulation

Function

Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.