CACNB2 — Calcium voltage-gated channel auxiliary subunit beta 2
CACNB2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CACNB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene nuclear transcripts Technical artifact | ABO, AIG1, ATRN, FOXN3, IMMP2L, KCNJ3, PLA2R1, TIAM2 | View in SCUBA |
About the gene
| Synonyms | CACNLB2, MYSB |
|---|---|
| Chromosome | 10: 18140424-18543557 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Transporters |
| Molecular function | Calcium channel, Ion channel, Voltage-gated channel |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.