ABRAXAS1 — Abraxas 1, BRCA1 A complex subunit
ABRAXAS1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABRAXAS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | ATP10A, BACH2, CASP10, FBLN5, GKAP1, HSBP1L1, MCUB, NUCB2 +9 more | View in SCUBA |
About the gene
| Synonyms | ABRA1, ABRAXAS, CCDC98, FAM175A, FLJ13614 |
|---|---|
| Chromosome | 4: 83459517-83523348 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Molecular function | Chromatin regulator |
| Biological process | DNA damage, DNA repair |
Function
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.