BACH2 — BTB domain and CNC homolog 2
BACH2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BACH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Germinal center B-cell B cell maturation | BCL6, BPTF, GGA2, MAP4K4, MBD4, MCTP2, MSI2, NR3C1 +7 more | View in SCUBA |
| CD4⁺ T cells | Naive T cell T cell development | ABRAXAS1, ATP10A, CASP10, FBLN5, GKAP1, HSBP1L1, MCUB, NUCB2 +9 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell T cell maturation | ADK, AIF1, ARHGAP15, ARMH1, CCR7, CNR2, DPYD, FAM117B +7 more | |
| Mucosal-associated invariant T cell | Naive T cell T cell maturation | AK5, ARID5B, CCR7, CSGALNACT1, FHIT, FOXP1, LEF1, MAL +6 more |
About the gene
| Synonyms | BTBD25 |
|---|---|
| Chromosome | 6: 89926528-90296843 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.