Naive T cell
Gene co-expression module in CD4⁺ T cells
| Category | T cell development |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes TCF7 and BACH2 are master regulators of naive/memory T-cell maintenance and quiescence; SGK1, PRKCA, NUCB2 support a resting/naive CD4 T-cell program. TCF7 marks naive/stem-like T cells, BACH2 represses effector differentiation. The module reflects a naive/quiescent CD4 T-cell state rather than effector activation. Mostly uniform expression and no contamination.
Genes
ABRAXAS1, ATP10A, BACH2, CASP10, FBLN5, GKAP1, HSBP1L1, MCUB, NUCB2, PRKCA, RETREG1, SGK1, SLC16A7, SYPL1, TCF7, TMEM123, TTC9, ZNF844
Most correlated modules
- T cell signaling · correlation 0.88
- Naive resting T cell · correlation 0.76
- T cell quiescence · correlation 0.73
- Naive T cell · correlation 0.72
- Hypoxia metabolic stress · correlation 0.71
- Immediate early activation · correlation 0.70
- Naive T quiescence · correlation 0.68
- TCR signaling · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.