MCUB — Mitochondrial calcium uniporter dominant negative subunit beta
MCUB belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MCUB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | ABRAXAS1, ATP10A, BACH2, CASP10, FBLN5, GKAP1, HSBP1L1, NUCB2 +9 more | View in SCUBA |
| Endothelial | IL33 Alarmin Signaling Inflammation | ARHGAP26, CHN1, DOC2B, IL33, PTAFR, SDCBP, SLC8A1, STMN3 +1 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell State T cell maturation | ARL14EP, CCR2, CD27, CD28, CD40LG, CD82, CNN2, CPNE2 +19 more | |
| Mucosal-associated invariant T cell | Cytotoxic Effector cytotoxicity | ANXA4, CCM2, CD320, CST7, DYNLRB1, GZMM, LIMD2, MGMT +10 more |
About the gene
| Synonyms | CCDC109B, FLJ20647 |
|---|---|
| Chromosome | 4: 109560209-109688719 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Negative regulator of the mitochondrial calcium uniporter (MCU), a channel that mediates calcium uptake into the mitochondrial matrix. MCUB is required to limit mitochondrial calcium overload during stress. Acts as a dominant- negative regulator that displaces MCU from the functional uniplex complex and thereby decreases the association of calcium sensors MICU1 and MICU2, preventing channel gating. Mitochondrial calcium homeostasis plays key roles in mitochondrial metabolism. Acts as an important regulator of mitochondrial metabolism in response to stress in muscle cells: induced in response to fasting, leading to restrict mitochondrial calcium uptake, resulting in reprogramming of mitochondria toward fatty acid oxidation preference (By similarity). Acts as a regulator of macrophage polarization during skeletal muscle regeneration: inhibition of mitochondrial calcium uptake drives differentiation of macrophages with anti-inflammatory profile, promoting the differentiation and fusion of satellite cells (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.