FBLN5 — Fibulin 5
FBLN5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FBLN5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | ABRAXAS1, ATP10A, BACH2, CASP10, GKAP1, HSBP1L1, MCUB, NUCB2 +9 more | View in SCUBA |
| Endothelial | Inflammatory Angiogenesis Inflammation | AZIN1, DHH, FILIP1L, GJA5, ITSN2, NUDT4, OCIAD2, PIK3C2B +6 more | View in SCUBA |
| Fibroblasts | Elastic Fiber ECM ECM production | ADD3, ASPA, FRMD3, PLTP, SLC29A1, SLIT2, SVEP1, TNXB | View in SCUBA |
| Lymphatic endothelial | Hypoxia HIF Response Stress | AKR1C1, AKR1C2, AKR1C3, ATP1A1, BNIP3, CARHSP1, CSRP2, CTSS +4 more | View in SCUBA |
About the gene
| Synonyms | ARMD3, DANCE, EVEC, UP50 |
|---|---|
| Chromosome | 14: 91869411-91947987 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.