ATP10A — ATPase phospholipid transporting 10A (putative)
ATP10A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP10A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | ABRAXAS1, BACH2, CASP10, FBLN5, GKAP1, HSBP1L1, MCUB, NUCB2 +9 more | View in SCUBA |
| Gamma-delta T cells | Lysosomal Biogenesis Protein processing & ER | ABI3, APLP2, B3GALT4, BAX, CD63, CTNNA1, DOCK5, EML2 +14 more | |
| Hematopoietic progenitor cells | ILC/NK Development Lymphcyte development | ACY3, ADGRD1, CCDC141, CD3E, CYSLTR1, ID2, ITGB7, NFATC4 +7 more | |
| Smooth muscle cells | Vasoconstrictor Signaling Contractility | ARHGAP29, BBX, CDK18, CSRP2, EDNRA, GPAT2, NR3C1, NUDT4 +4 more | View in SCUBA |
About the gene
| Synonyms | ATP10C, ATPVA, ATPVC, KIAA0566 |
|---|---|
| Chromosome | 15: 25677273-25865184 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins, Transporters |
| Molecular function | Translocase |
| Biological process | Lipid transport, Transport |
Function
Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.