ACOT8 — Acyl-CoA thioesterase 8
ACOT8 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACOT8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Lipid Xenobiotic Metabolism Nutrient processing | ACAA1, ARF3, ATG4D, BPNT1, BSG, CA12, CNPPD1, CRAT +15 more | View in SCUBA |
About the gene
| Synonyms | hACTE-III, hTE, NAP1, PTE-2, PTE1 |
|---|---|
| Chromosome | 20: 45841721-45857405 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Serine esterase |
| Biological process | Fatty acid metabolism, Host-virus interaction, Lipid metabolism, Peroxisome biogenesis |
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation. (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.