CRAT — Carnitine O-acetyltransferase
CRAT belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CRAT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Lipid Xenobiotic Metabolism Nutrient processing | ACAA1, ACOT8, ARF3, ATG4D, BPNT1, BSG, CA12, CNPPD1 +15 more | View in SCUBA |
About the gene
| Synonyms | CAT1 |
|---|---|
| Chromosome | 9: 129094142-129111189 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Fatty acid metabolism, Lipid metabolism, Transport |
Function
Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta- oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2- enoyl-CoAs and 2-methylacyl-CoAs are poor substrates.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.