Lipid Xenobiotic Metabolism
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include CA12 (carbonic anhydrase/ion transport), SULT1A1/CYP4F12 (xenobiotic/sulfate metabolism), SLC27A4/ACAA1/ACOT8 (fatty acid transport and oxidation), PLCD1/PLCD3/PLD1/INPP5J (phospholipid signaling), and BSG (metabolic chaperone). The module is core coherent with mild sen_colono enrichment, representing lipid handling and xenobiotic detoxification in colonocytes. Phospholipid signaling genes co-occur with lipid metabolic genes, consistent with a colonocyte lipid/xenobiotic metabolism program.
Genes
Most correlated modules
- Mature Colonocyte Identity · correlation 0.87
- Lipid Metabolism · correlation 0.81
- Colonocyte Detoxification · correlation 0.80
- Colonocyte Solute Transport · correlation 0.80
- Brush Border Cytoskeleton · correlation 0.78
- PPARG Lipid Metabolism · correlation 0.74
- Fatty Acid Oxidation · correlation 0.74
- Mature Colonocyte Metabolism · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.