GPCR-AKT-MAPK Signaling
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 38 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 38 genes have a known function matching the annotation |
Why this annotation
Top hub genes are GNB1 (G-protein beta-1), GNAS (G-protein alpha-s), GRK2 (G-protein coupled receptor kinase 2), AKT1 (PI3K-AKT signaling), MAP2K2 (MEK2, RAS-MAPK pathway), CSNK2A2 (CK2 kinase), and VEGFB. This is a coherent GPCR-coupled intracellular signal transduction module (G-protein -> kinase cascades). Supporting genes CTBP1, BRD4, ALYREF reflect downstream transcriptional effectors. The module reflects tonic/basal kinase signaling activity uniformly across gd T cell subsets, consistent with housekeeping-level survival and proliferative signaling.
Genes
ADNP, AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB, CLPTM1L, CSNK2A2, CTBP1, DUS1L, EIF3B, ELOC, ENTR1, GATAD2A, GNAS, GNB1, GRK2, JUND, MAP2K2, MBD2, MCRIP2, METRN, NCK2, PCBP1, PGP, PHC2, PLEKHM2, PPP1R14B, SAMD1, SH3GLB2, SRM, STK24, TMEM238, UBALD2, UBE2M, VEGFB
Most correlated modules
- Polycomb Transcriptional Control · correlation 0.76
- Chromatin-Splicing Regulation · correlation 0.75
- snRNP Splicing · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.