BRD4 — Bromodomain containing 4
BRD4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BRD4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | GPCR-AKT-MAPK Signaling TCR Signaling | ADNP, AKT1, ALYREF, B3GALT6, BRI3, BTBD6, CENPB, CLPTM1L +29 more | |
| Innate lymphoid cells | ILC3 identity Differentiation | BHLHE40, CASK, CITED2, GLUL, GNAS, HECA, IGFBP7, IQGAP1 +19 more | View in SCUBA |
| Lymphatic endothelial | Basement Membrane ECM migration & adhesion | COL4A1, COL4A2, GOLGA4, ITGAV, PITPNB, PXDN, RAI14, RB1CC1 +4 more | View in SCUBA |
| Macrophages | Chromatin Regulatory Genes Housekeeping | ACAP2, ARID4A, ATRX, BPTF, BRD10, EP300, ERBIN, ETNK1 +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | PI3K MAPK Signaling TCR Signaling | AKT1, APH1A, CALM2, CMTM3, DAZAP1, GNAS, GRK2, MAP2K2 +11 more |
About the gene
| Synonyms | CAP, HUNK1, HUNKI, MCAP |
|---|---|
| Chromosome | 19: 15235519-15332545 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator |
| Biological process | DNA damage, Host-virus interaction, Transcription, Transcription regulation |
Function
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II. According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo. In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B. Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters. Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.