DOCK2 — Dedicator of cytokinesis 2
DOCK2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DOCK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Response DNA/chromatin regulation | AP1B1, CCAR1, CHD8, EP400, ERBIN, GOLM2, IPO8, LRBA +17 more | |
| Macrophages | Chromatin Remodeling Housekeeping | ADIPOR2, ADNP, AP2A2, APPL2, ATF2, CDK19, CNOT1, CTDSPL2 +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Migration migration & adhesion | AP3B1, ATP9B, BIRC6, BTBD9, CEP350, DOCK11, ERBIN, FRYL +8 more | |
| Neutrophils | ELMO-DOCK Chemotaxis Chemotaxis | BCAS3, CDK19, ELMO1, KMT2C, NCOA2, STAG1, VPS13B |
About the gene
| Synonyms | KIAA0209 |
|---|---|
| Chromosome | 5: 169637268-170083382 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.