BRI3 — Brain protein I3
BRI3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BRI3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Mature colonocyte absorptive Absorption | ADI1, BTG1, CAMK2N1, CTSZ, FXYD3, GUCA2A, GUCA2B, HSD17B2 +9 more | View in SCUBA |
| Gamma-delta T cells | GPCR-AKT-MAPK Signaling TCR Signaling | ADNP, AKT1, ALYREF, B3GALT6, BRD4, BTBD6, CENPB, CLPTM1L +29 more | |
| Goblet cells | Notch Target Response Epithelial development | CLDN3, GDF15, HES1, ID1, KLF10, NRARP, TRAF4 | View in SCUBA |
| Lymphatic endothelial | Actomyosin Cytoskeleton Cytoskeletal | CD63, CFL1, CHCHD2, COX4I1, EDF1, GABARAPL2, HINT1, LGALS3 +8 more | View in SCUBA |
| Macrophages | Glycolytic Redox Metabolism Lipid metabolism | AGPAT2, ANXA5, ATP6V1F, BCKDK, C1orf122, CLIC1, ELOC, ENO1 +18 more | View in SCUBA |
| Smooth muscle cells | Translation initiation/RNA-binding RNA processing & translation | CDV3, EIF5, EPC1, FAM133B, FAM53C, FUS, MAFB, PPP1R10 +2 more | View in SCUBA |
About the gene
| Chromosome | 7: 98252379-98310441 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.