ADSL — Adenylosuccinate lyase
ADSL belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADSL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | AP1S1, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23, ETFB +20 more |
About the gene
| Chromosome | 22: 40346461-40390463 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Lyase |
| Biological process | Purine biosynthesis |
Function
Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.