DDT — D-dopachrome tautomerase
DDT belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Oxidative Phosphorylation Mitochondrial & OxPhos | COX6A1, COX6C, ECHS1, HADHA, LGALS4, MGST3, NDUFA1, PRDX1 +3 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | ADSL, AP1S1, CD151, COMTD1, COX5A, DNPH1, DUSP23, ETFB +20 more | |
| Innate lymphoid cells | Mitochondrial Metabolic Housekeeping Mitochondrial & OxPhos | ALKBH7, ATF6B, BCAS1, COQ8A, DNAJC4, DPM3, EIF3M, FDFT1 +16 more | View in SCUBA |
| Smooth muscle cells | Rho GTPase Housekeeping Housekeeping | CDC42, CST3, OST4, POLR2L, PRELID1, RHOC, SCAND1 | View in SCUBA |
About the gene
| Synonyms | D-DT, DDCT, MIF-2, MIF2 |
|---|---|
| Chromosome | 22: 23970542-23980525 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Lyase |
| Biological process | Melanin biosynthesis |
Function
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.