AP1S1 — Adaptor related protein complex 1 subunit sigma 1
AP1S1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AP1S1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Glycosylation & trafficking Protein processing & ER | AASDHPPT, ABHD12, ACTR1A, ANKRD35, ARRDC1, ATF6B, ATG5, CDK19 +25 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | ADSL, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23, ETFB +20 more | |
| Innate lymphoid cells | Mitochondrial OxPhos Biogenesis Mitochondrial & OxPhos | ATOX1, ATP5ME, ATP5MF, C1QBP, CNIH1, CYC1, ERH, HSD17B10 +22 more | View in SCUBA |
About the gene
| Synonyms | AP19, CLAPS1, EKV3, SIGMA1A, WUGSC:H_DJ0747G18.2 |
|---|---|
| Chromosome | 7: 101154456-101161596 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Protein transport, Transport |
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.