Mitochondrial OxPhos
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 29 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 29 genes have a known function matching the annotation |
Why this annotation
Top hub genes include NDUFS8 (NADH:ubiquinone oxidoreductase, Complex I), COX5A (Complex IV), ETFB (electron transfer flavoprotein), VDAC1 (mitochondrial outer membrane channel), SLC25A39 (mitochondrial carrier), HINT2 (mitochondrial histidine triad protein), and PRDX5 (mitochondrial peroxiredoxin). Additional redox protection genes GPX4 and GSTP1 support mitochondrial ROS management. TPI1 adds glycolytic context. This is a well-defined mitochondrial oxidative phosphorylation and redox homeostasis module expressed uniformly at moderate levels.
Genes
ADSL, AP1S1, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23, ETFB, FIBP, FKBP1A, GPX4, GSTP1, HCFC1R1, HINT2, HMGA1, IFI27L2, ITM2A, LPIN2, MPC1, NDUFS8, PHPT1, PPA1, PRDX5, RGS10, SLC25A39, SMARCB1, TPI1, VDAC1
Most correlated modules
- Cellular Homeostasis · correlation 0.90
- DNA Repair Housekeeping · correlation 0.87
- Cell Cycle Entry · correlation 0.87
- Mitochondrial ETC · correlation 0.86
- Basal Lipid Metabolism · correlation 0.86
- Complex I Assembly · correlation 0.79
- Interferon Stimulated Response · correlation 0.76
- Metabolic Housekeeping · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.