ETFB — Electron transfer flavoprotein subunit beta
ETFB belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ETFB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon-stimulated genes Anti-viral | APOBEC3G, ARPC4, ARPC5L, BAK1, BST2, DCTN3, ECH1, FAM104A +14 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | ADSL, AP1S1, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23 +20 more | |
| Innate lymphoid cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ACTR10, ANP32A, APOL3, ATP6V1E1, ECHS1, ERCC1, GLRX3, HIGD1A +12 more | View in SCUBA |
| Lymphatic endothelial | Fatty Acid Oxidation Lipid metabolism | ATRAID, ECH1, ECHS1, FCGRT, NDUFB10, PEBP1, PRDX2, TMEM14C | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ACP1, ARPC5L, ATP6V1G1, AURKAIP1, C19orf53, CHMP2A, CIAO2B, CIB1 +31 more | View in SCUBA |
| Smooth muscle cells | OXPHOS Complex I Mitochondrial & OxPhos | CLTB, COPS6, IAH1, MRPS21, NDUFA2, NDUFB10, NDUFC2, OAT +3 more | View in SCUBA |
About the gene
| Chromosome | 19: 51345169-51366388 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | Electron transport, Transport |
Function
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.