AFMID — Arylformamidase
AFMID belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AFMID's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Autophagy Metabolic Stress Stress | ACKR3, DPEP2, EAF2, GPBAR1, NAP1L1, PKP2, SOD1, SPATA6 +1 more | View in SCUBA |
About the gene
| Synonyms | DKFZp686F03259, KF |
|---|---|
| Chromosome | 17: 78187358-78207702 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Tryptophan catabolism |
Function
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.