EAF2 — ELL associated factor 2
EAF2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EAF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Somatic Hypermutation B cell maturation | DEF8, HMCES, KLHL6, LBR, OGG1, PHF6, PRPSAP2, RFC1 +3 more | View in SCUBA |
| Macrophages | Cytoskeletal Migration Migration & adhesion | GLCCI1, PAK1, PALD1, SIGLEC10, TBC1D4, TPD52, UNC5B | View in SCUBA |
| Monocytes | Autophagy Metabolic Stress Stress | ACKR3, AFMID, DPEP2, GPBAR1, NAP1L1, PKP2, SOD1, SPATA6 +1 more | View in SCUBA |
About the gene
| Synonyms | BM040, TRAITS, U19 |
|---|---|
| Chromosome | 3: 121835183-121886526 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Apoptosis, Transcription, Transcription regulation |
Function
Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.